Pre-clinical medicine Books

Rudern wird von vielen Menschen in ihrer Freizeit als klassische Amateursportart betrieben. In diesem Buch behandeln Sportwissenschaftler die modernen Methoden der Leistungsdiagnostik und Trainingssteuerung am Beispiel Rudern...

This book records the proceedings of the 5th International Symposium on cancer topics organised in collaboration with the Association for International Cancer Research, a cancer charity based in the United Kingdom. The...

In the operation of reasoning, the mind does nothing but run over its objects, as they are supposed to stand in reality, without adding any thing to them or diminishing any thing from them. If I examine the Ptolomaic and...

About ten years aga devices and equipment were developed for producing quantitative images in vivo of the distribution of substanees with positron­ emitting radionuclide label of very short half-life (down to only several...

On February 21 and 22, 1975, an International Workshop on the "Genetics of Diabetes Mellitus" was held in Göttingen, West-Germany. This workshop had been organized hy the Department of Medicine, University of Göttingen, and was...

This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach...

This comprehensive volume captures the latest scientific evidence, technological advances, treatments and impact of biotechnology in hyperbaric oxygen therapy. Divided into three distinct sections, the book begins with basic aspects that include history,...

This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80's. However, the advances of deep-sequencing technologies...

Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists,...

Cushing´s syndrome is a rare disorder that is associated with many co-morbidities such as systemic hypertension, diabetes, osteoporosis, impaired immune function, and psychiatric disease, all of which severely reduce quality of life and life...

This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology...

This book provides an elaboration and evaluation of the dominant conceptions of genetic counseling as they are accounted for in three different models: the teaching model; the psychotherapeutic model; and the responsibility model. The elaboration of...

AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including...

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both...

This book offers a comprehensive introduction to using Mathematica and the Wolfram Language for Bioinformatics. The chapters build gradually from basic concepts and the introduction of the Wolfram Language and coding paradigms in Mathematica, to detailed...

This book provides a cutting-edge review of polyglutamine disorders. It primarily focuses on two main aspects: (1) the mechanisms underlying the pathologies' development and progression, and (2) the therapeutic strategies that are currently being...

This book provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters...

This book focuses on all of the major problems associated with the absence of body weight in space, by analyzing effects, adaption, and re-adaptation upon returning to Earth, using sound scientific principles embedded in a historical context. Serious...

The book contains recent research about physiology,psychology, nutrition and training aspects of Marathon Running of differentage, gender and performance level. The basic knowledge of marathon running withexplanations of the physiological and...

This book examines the new knowledge that has been gained from the objective monitoring of habitual physical activity by means of pedometers and accelerometers. It reviews current advances in the technology of activity monitoring and details advantages...

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues...

This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal...

Presenting the most current and relevant information on the diagnosis and management of primary ovarian insufficiency, also known as premature ovarian failure (POI/POF), this book presents two equally important voices. The first is the scientific,...

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of...

This timely, concise title provides an important update on clinical lipid management. Using information from recent clinical trials and in special populations, the book begins by offering an easy-to-read overview of LDL, HDL, and triglyceride metabolism...

​In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe ...

The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured...

When we worked on Down Syndrome brain in the past we have been focus­ ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced...

Walther Birkmayer, one of the co-discoverers of the neuro­ chemical causes of Parkinson's disease and of its treatment by neurotransmitter-replacement therapy, and his former col­ laborator and colleague Peter Riederer have...

Der rasch zunehmende Wissensstand auf dem Gebiet der angeborenen, unspezi- schen Immunität wird laufend in einer Vielfalt ausgezeichneter Monographien fest- halten, in denen hervorragende Wissenschafter ihr Fachgebiet ...

Sildenafil, for the treatment of erectile dysfunction, is one of the first products that has made its way successfully from basic NO (nitrous oxide) research, to clinical routine therapy.  Sidenafil, part of the Milestones...

A wealth of information has accumulated over the last few years on the human genome. The new insights have completely changed the focus of protein analysis. It is no longer time-consuming analysis of unknown products, but...

In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and...

GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is,...

An up-to-date and comprehensive review of the discipline of imaging of the knee. The first part discusses the various techniques employed when imaging the knee. Individual chapters are devoted to radiography, arthrography, computed tomography and CT...