Pharmacology Books

Since 1994, the Phytochemical Society of North America has devoted its annual symposia to topics with biological perspectives. Our last four volumes have dealt with medicinal plants (1994), plant/insect interactions (1995),...

Eulogy for Karen Wetterhahn: As an Introduction to the Session "Genetic Response to Environmental Exposure to Metals" for the Second International Symposium on Metals and Genetics.- Genetic Response to Environmental Exposure to Metals and Metal Transport...

Because progress in the field of transporters has been extraordinary, this volume will focus on recent advances in our understanding of the structure, function, physiology, and molecular biology of membrane transporters...

This authored book presents basic immunological tenets and mechanisms at the cellular and molecular level while employing the toxicology focus on hazard identification, appropriate assays, dose response, and risk assesment...

Aldehyde Dehydrogenasé.- 1. The Big Book of Aldehyde Dehydrogenase Sequences: An Overview of the Extended Family.- 2. Reaction-Chemistry-Directed Sequence Alignment of Aldehyde Dehydrogenases.- 3. Three-Dimensional Structure of Mitochondrial Aldehyde...

Preface; S. Nigam, C.R. Pace-Asciak. Introductory Remarks: Historical Roots and Contemporary Aspects of Lipoxygenase Research; T. Schewe, et al. Part I: Enzymology, Molecular Biology, and Biological Functions of Mammalian Lipoxygenases. Mammalian...

1. Antibiotic Resistance: The Big Picture; D. Mazel, J. Davies. 2. Clinical impact of Antibiotic Resistance; S.A. Lerner. 3. Reversing Tetracycline Resistance: A Renaissance for the Tetracycline Family of Antibiotics; S.B. Levy, M. Nelson. 4...

Flavonoids in the Living System: An Introduction; J.A.Manthey, B.S. Buslig. Flavonoids and Arbucular-Mycorrhizal Fungi; H. Vierheilig, et al the Role of Glycosylation in Flavonol-Induced Pollen Germination; L.P. Taylor, et al. Expression of Genes for...

Saponins and Plant Defense; A.E. Osbourn, et al. Role of Toxins in Plant Microbial Interactions; S.P. McCormick, et al. Active Oxygen in Fungal Pathogenesis of Plants; The Role of Cercosporin in Cercospora Diseases; M.E. Daub, et al. Tree-Fungus...

Cellular Mechanisms Involved in the Modulation of the Immune System by Drugs of Abuse; S.L. Chang, et al. Immunomodulation of Macrophage Functions by Opioids; R. Gomez-Flores, R.J. Weber. Morphine Accelerates the Progression of Sepsis in an...

Aldehyde Dehydrogenase. Crystal Structure of a Class 3 Aldehyde Dehydrogenase at 2.6angstrom Resolution; Z-J. Liu, et al. Conserved Residues in the Aldehyde Dehydrogenase Family: Locations in the Class 3 Tertiary Structure; J. Hempel, et al. Class 3...

Ocular Electrophysiology: Retinal Toxicology Study Using Electrophysiological Methods in Rabbits; Y. Shirao, K. Kawasaki. Experimental Study of the Retinal Toxicity of Iron after Vitreous Hemorrhage; W.J. Nie, X.F. Zhang. Ocular Pharmacokinetics: ...

The Role of Nutrition in Wound Healing (S.J. Dudrick). Chronic Wounds: Growth Factors and Comprehensive Surgical Care (D.R. Knighton). Wound Healing and Infection (D.E. Fry). The Plug Repair for Recurrent Inguinal Hernias (A.G. Shulman). Open ...

Perspective of Neurochemistry in Neurological Disorders.- Selegiline Induces "Trophic-Like" Rescue of Dying Neurons without Mao Inhibition.- Aliphatic Propargylamines, a New Series of Potent Selective, Irreversible Non-Amphetamine-Like MAO-B Inhibitors.-...

Pineal Gland Regulation: Expression of Neurotransmitter Receptor Subtypes and Subunits in the Mammalian Pineal Gland; M. Møller, et al. Transcription Factor Icer and Regulation of Rat Photoneuroendocrine System; J.H. Stehle. Intracellular Actions of...

Mechanism of Action and Rationale for the Use of Biological Response Modifiers, Differentiating Agents and Nucleoside Analogues in Combination: Cytokine Synergy in Immunotherapy (J.W. Hadden et al.). Monitoring Combination Therapy Trials (J.L...

Pathophysiology and Analysis.- Lipid Peroxides and Related Radicals in Clinical Medicine.- Reactive Oxygen Species in Normal Physiology, Cell Injury and Phagocytosis.- Free Radical Mechanisms for Chromosomal Instability in Bloom's Syndrome.- The Analysis...

Design of New Types of Antitumor Nucleosides (A. Matsuda et al.). Lithiation Chemistry of Uridine Derivatives (H. Tanaka et al.). A Synthesis of 2'Fluoro and 3'FluoroSubstituted Purine Nucleosides via a Direct Approach (K.W. Pankiewicz, K.A...

Pharmaceutical scientists in industry and academia will appreciate this single reference for its detailed experimental procedures for conducting biopharmaceutical studies. This well-illustrated guide allows them to...

The Nitric Oxide Signal Transduction System (F. Murad). Chemistry and Biochemistry of Nitric Oxide: Mechanisms of Mammalian Nitric Oxide Biosynthesis (P.L. Feldman et al.). Nitric Oxide Synthase Inhibitors: Mechanisms of Action and in vivo Studies...

1. Site Directed Mutagenesis to Probe for Active Site Components of Liver Mitochondrial Aldehyde Dehydrogenase.- 2. Substrate Binding Pocket Structure of Human Aldehyde Dehydrogenases: A Substrate Specificity Approach.- 3. Human Class 1 Aldehyde...

Eric Neil: An Appreciation.- International Meetings on Chemoreceptors: Historical Perspectives.- Oxygen Sensing in the Carotid Body: Ideas and Models.- Ionic Channels in Type I Carotid Body Cells.- Role of Intracellular pH and [Ca2+]iin Acid...

Experience with Contraceptive Side Effects: Selection of a Contraceptive; P. Senanayake. Contraceptives and Women's Complaints; Y. Ahmed, S. Boccard. Variability in Steriod Pharmacokinetics: Population and Delivery Systems; J. Garza-Flores, et al...

Symposium Presentations.- Chemotactic and Inflammatory Cytokines: CXC and CC Proteins.- Induction of Chemotactic Cytokines by Minimally Oxidized LDL.- The Immunopathology of Chemotactic Cytokines.- Receptor/ligand Interactions in the C-C Chemokine Family...

Angiotensin II Receptor (T. Inagami et al.). Molecular Biology of Angiotensin II Receptors (B. Lassègue et al.). Defining Angiotensin Receptor Subtypes (A.T. Chiu et al.). Medicinal Chemistry of Angiotensin II Antagonists (W.J. Greenlee, R.W. Wexler)...

Fluoropyrimidine Metabolism and Mechanism of Action.- 5-Fluoro-2?-Deoxyuridine: Role of Schedule in its Therapeutic Efficacy.- Comparison of Continuous Infusions and Bolus Injections of 5- Fluorouracil with or without Leucovorin: Implications for...

Mechanistic Approaches to Antimutagenesis and Anticarcinogenesis: Multiple Mechanisms; L.M. De Luca. Inhibition of Mutagenesis and Carcinogenesis by Extracellular Mechanisms: Inhibition of Nitrosation; H. Bartsch, et al. Modulation of Metabolism and...

Stress, the Hypothalamic-Pituitary-Adrenal Axis, and Immune Function; M. Stein, A.H. Miller. Psychological Stress, Immunity and Immune Depression; A. Falek. Opiods, Receptors, and Immunity; M.W. Adler, et al. Consequences of Opiate-Dependency in a...

Peptides: Vasoactive Intestinal Peptide; I. Gozes, D.E. Brenneman. Proteases for Neuropeptide Precursor Processing in Bovine Adrenal Medullary Chromaffin Granules; V.Y.K. Hook, et al. Growth Factors: Gene Transfer into the Central Nervous System; D.M...

The Use of Derivatives of MSH for Targeting to Melanomas In Vivo; D.R. Bard, et al. The Development of Ricin AChain Immunotoxins for Clinical Trials in Patients with Hodgkin's Disease; A. Angert, P. Thorpe. Ribosome-Inactivating Proteins from...

Cellular Barriers: The Paracellular Pathway; M. Cereijido, et al. Ectopeptidases; N.M. Hooper. Epithelial Barriers: Macromolecular Transport Across the Intestinal Epithelium; M. Neutra, J.P. Kraehenbuhl. Oral Cavity; H.P. Merkle, G. Wolany. Vascular...

Aldehyde Dehydrogenases-The 1992 Perspective.- Metabolic Role of Aldehyde Dehydrogenase.- Effects of Aldehyde Products of Lipid Peroxidation on the Activity of Aldehyde Metabolizing Enzymes in Hepatomas.- Metabolic Interactions of 4-Hydroxynonenal,...

Opening Speech; E.D. Hondros. Welcome Address; H.H. van der Kroonenberg. Safety and Efficacy in Boron Neutron Capture Therapy; D. Gabel. Some Aspects of BNCT at the Brookhaven National Laboratory; D.D. Joel, et al. INEL BNCT Program Directions with...

The Development of the Vascular System: Embryonic Development of Blood Vessels; F. Dieterlen-Liévre, L. Pardanaud. Regulation of Embryonic Blood Vessel; H. Drexler et al.. Biology of Endothelial Cells and Angiogenesis: Basic Fibroblast Growth Factor...

Introductory Address.- The New Biology and Vaccine Research.- Keynote Presentation.- Mucosal Immunity To Vaccines: Current Concepts for Vaccine Development and Immune Response Analysis.- Session I: Oral Diseases and Host Immune Responses.- Prospects for...

Phospholipases A2: Brain Phospholipases and their Role in Signal Transduction; A.A. Farooqui, et al. Cell Signaling and Essential Fatty Acids: Reciprocal Regulation of Fatty Acid Release in the Brain by GABA and Glutamate; D.L. Birkle Metabolites of...

Outstanding Problems in Cancer Risk Assessments: Pharmacodynamic Models for Cancer Risk Assessment; S.H. Moolgavkar. Oncogenes: Review of Current Status and Potential for Contributions to Cancer Risk Assessment Methods: Oncogene Assessment and Human...

Progress in the Development of Natural Products for Human Immunodeficiency Viruses Infections (R.F Schinazi). StructureActivity Correlations of Natural Products with AntiHIV Activity (M. Nasr et al.). AIDSAntiviral Natural Products Research at the US...

Combination Immunotherapy: Immune Therapy of Human Cancers (R.P. Gale, A. Butturini). Clinical Applications of Combination Chemoimmunotherapy in Cancer: Combination of Fluorouracil and Interfon (R. Pazdur). Combination Approaches and Gene Therapy...

Histopathology of Bronchial Asthma; P.K. Jeffery. Airway Neuropeptides; P. Barnes. Potential Role of Mast Cell Proteases in Asthma; J. Nadel. Human Mast Cells, Basophils, and their Mediators; V. Casolaro, et al. Platelets and Asthma; J. Morley, et al...

Characteristics of Hypoxic Cells that Enhance their Susceptibility to Chemical Injury.- Prediction and Measurement of Redox Properties of Drugs and Biomolecules.- Metal-Catalyzed Redox Processes in Biological Systems and Drug Activation.- Redox Systems...

Native Fibrin Gel Networks and Factors Influencing their Formation in Health and Disease.- The Structure and Evolution of Vertebrate Fibrinogen: A Comparison of the Lamprey and Mammalian Proteins.- Nucleotide Sequences of the Three Genes Coding for Human...

1 Characteristics of Multidrug Resistance in Human Tumor Cells.- 2 Development of Multidrug Resistance in Rodent Cell Lines.- 3 Cloning and Characterization of Mouse mdr Genes.- 4 Isolation and Characterization of the Human MDR (P-Glycoprotein) Genes.- 5...

Microinjection (G. Sczakiel et al.). How to Make Glass Microtools for the Injection of Isolated Plant Sperm Cells into Embryo Sac Cells Using a Microforge (C.J. Keijzer). Application of Confocal Microscopy for the Study of Neuronal Organization in...

Molecular Polymorphism: Biosynthesis of the Molecular Forms of Acetylcholinesterase (J. Massoulie et al.). Molecular Organization of Recombinant Human Acetylcholinesterase (B. Velan et al.). Nematode Acetylcholinesterases (M. Arpagaus et al.). ...

I. Historical Perspectives.- I. Historical Perspective.- II. Colorants for Electronics.- 1. Liquid Crystal Dyes.- 1.1. Introduction.- 1.2. Dye Types.- 1.3. Future Trends.- 1.4. Summary.- References.- 2. Micro Color Filters.- 2.1. Introduction.- 2.2. Flat...