Oncology Books

The contemporary management of patients with cancers of the head and neck is under careful scrutiny and major changes are being introduced in order to improve the potenti­ al not only for long-term control but also for less in...

The acquired immunodeficiency syndrome (AIDS) and the AIDS­ related complex (ARC) are caused by the human immunodeficien­ cy virus (HIV-I), previously known as human T-celllymphotropic virus type III (HTLV-III) or ...

Physicians, biologists and physicists present their recent work in the field of hyperthermia with regard to both its application and its combination with radiation and chemotherapy. Current technical possibilities, clinical...

Basic research has thrown new light on the importance of free radicals in biol­ ogy and medicine. The clarification of interactions opens numerous physio­ logical and pathological processes to closer scrutiny. The ...

In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of...

Since the small bowel except the duodenum and (1961), Pygott et al. (1960), Gianturco (1967) terminal ileum is largely inaccessible during en­ and Bilbao et al. (1967). doscopic examination, radiology of the small Sellink,...

Tumour therapy depends essentially on being able to destroy the clonogenic activity of tumour cells while keeping the damage to the normal tissue low. Clinical experience shows that tumour response varies greatly even if...

One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive...

H.-J. Senn Adjuvant Chemotherapy (ACT) of breast cancer has now emerged as one of the controversial su):>jects in clinical and also experimental oncology. Driven by growing frustration about stagnating cure rates in breast...

Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity. The advantages of...

Several papers dealing with the clinical relevance of steroid hormone receptors in breast cancer have already been published. However, no publication has overviewed studies currently being conducted in Europe, nor is there a...

The enormous expansion seen over the last decade in the mammo­ graphic detection of breast cancer lesions, especially the use of screen­ ing procedures for the early detection of clinically unsuspected tumors, has made it...

This book comprises the lectures presented at the workshop Modified Nuc1eosides and Cancer held from 28 September to 2 October, 1981 in Freiburg, West Germany. The workshop was organized by Gisela Nass and sponsored by the...

The life of a human being is finite, and all humans age (see Fries 1980). It is difficult to separate the effects of disease on organs and tissues from those expected of aging. This is particularly true for vascular and...

Substantial relief of discomfort may be anticipated by most patients suffering from pelvic and lower-extremity pain who are treated by arterial infusion of nitrogen mustard. Seventy-three patients with intractable pain...

Transplantation of syngeneic (donor is a monozygous twin) or allogeneic (donor is an HLA-identical sibling) marrow provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity. Until 1975,...

Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in...

The Analog Potential in Cancer Chemotherapy in the United States and Japan S. K. Carter Northern California Cancer Program, 1801 Page Mill Road, Building B, Suite 200, USA - Palo Alto, CA 94304 The bilateral collaborative...

Progress in basic research has made it necessary to redetermine the possibility of classic endocrine therapy for the treatment of patients with breast cancer. Exemplary, close cooperation between biochemis­ try and animal and...

Since cytotoxic drugs were first developed, their damaging effects on bone marrow have attracted considerable interest. We now know that the bone marrow is an organ with rapid cell renewal in which maintenance of the ...

The purpose of this monograph is to address the basic mecha­ nisms for organizing trials. Is is meant to serve as a guide to individuals planning to form a cooperative group as well as to cooperative groups who wish to revise...

Hairy-cell leukaemia (HCL) is an established clinicopathological entity typified by a chronic picture of substantial splenomegaly, less frequent hepatomegaly, and only inconspicuous lymphadenopathy. Central to the diagnosis is...

A prospective randomized clinical trial of treatment with vincristine, cyclophosphamide, methotrexate and 5-fluorouracil after conventional curative treatment for stage II breast cancer is described. The results at 2 years are...

P. Denoix and G. Mathe Approximately 70% of cancer patients relapse after surgery before the 5th year and, in most cases, for example in breast carcinoma, they relapse still later up to the 20th year. For some considerable...

We have studied 24 cases of secondarily leukemic (stage V) lymphosarcoma (LS), 31 cases of "d'emblee" leukemic LS, and ten cases of lymphoid leukemic neoplasias transitional between "d'emblee" leukemic LS and chronic ...

Tactics is the art of combining the action of troops or the proper means of different arms with the object of obtaining the maximum success at combat. Strategy is the art of combining the action of aB the military forces with a...

The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been...

E. GRUNDMANN, and W. VAHLENSIECK In recent years tumors of the male genital system have acquired a new scientific importance in many respects: First, epidemiologic studies have revealed a striking increase of prostate carcinoma...

A.G. STANSFELD, and J.A.M. VAN UNNIK. In joint discussions in 1974, the Club worked out a new terminology that was acceptable to all members and will hopefully be acceptable to other pathologists. Since then, it has been called...

When asked why he robbed banks, an astute and success­ ful criminal is said to have replied "Because that's where the money is kept." Why study patients with multiple primary cancers? The answer follows the same practical...

Fresh living Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them highly cytotoxic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14...

Bone Tumors - A Challenge for Cooperation E. GRUNDMANN Among the wide variety of human tumors, those of the skeletal system have an exceptional position in several respects. Above all, they are comparatively rare, and that is...

Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and...

E. GRUNDMANN The question as to whether cytostatic drugs might be carcinogenic has been presented and discussed in three experimental studies. The most extensive in­ vestigations were by J. H. WEISBURGER and coll. (New York,...

The Pros and Cons of Cancer Registration E. Grundmann It may seem strange for somebody to hold a symposium on cancer regis­ tration and then submit a paper under the heading "The Pros and Cons of Cancer Registration." Indeed,...

K. MUSSHOFF The group of diseases known as malignant lymphomas are, for a number of reasons, of equal interest to theoretical and clinical medicine. New findings in the fields of virology and immunology could conceivably shed...

E. GRUNDMANN On behalf of the "Gesellschaft zur Bekampfung der Krebskrankheiten Nordrhein­ Westfalen e. V. " I welcome you in Dusseldorf. During these two days problems of oncogenesis have to be discussed. The participants have...

The geography of medicine is a classical subject that can be studied wherever medicine is practised and the population counted. It has already contributed a great deal to knowledge of the causes of disease and it might be...

The diagnosis of osteoporosis and the determination of fracture risk has always been a challenge for radiologists, epidemiologists, and clinicians as well as oth­ er researchers and health care professionals working in the...

The imaging potential of the MR experiment continues to evolve. In recent years, an increasing number of fast and ultrafast imaging strategies has been described. In this evolu­ tion the definition of the terms fast and...

Interest in the general field of tumor immunology has grown phenomenally in recent years. The number of publications con­ tinues to grow in seemingly exponential fashion and the end is not yet in sight. Under these conditions,...