Molecular biology Books

Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic...

This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term...

Biological systems inherently possess much ambiguity or uncertainty. Computational electrophysiology is the one area, from among the vast and rapidly growing discipline of computational and systems biology, in which...

The nucleolus had consistently attracted the attention of investigators in the fields of cell biology and pathology. Because of its ubiquitous presence in the nucleus of eukaryotic cells, its rapid changes during their life...

In 1977 I wrote a grant proposal in which I applied to study developmental patterns in enzymatic methylation of DNA in eukaryotes. One part of the proposal was to assay cells at different embryonic developmental stages for...

l RNA tumor viruses have become increasingly utilized in studies of cellular transformation and gene regulation. The genes of retroviruses exist in two forms; as extrachromosomal, RNA-containing, infectious particles and as DNA...

Die auBerordentlich umfangreiche Literatur, welche wahrend del' letzten 25 Jahre, VOl' allem abel' gerade in del' letzten Zeit auf dem Gebiete del' pflanzlichen sowie del' synthetischen Zellstreckungswuchsstoffe erschienen ist,...

In modern scientific investigation the fields of biochemistry, molecular biology, and morphology comprise an indivisible area of study. The present book results from the cooperation of a bioehernist and morphologists: the...

In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in...

The book focuses on the lymphatic vascular system from a developmental biologist's point of view. It provides an overview on the many recent advances in understanding the development of lymphatic vessels, using advanced genetic models in conjunction with...

Auxin is an important signaling compound in plants and vital for plant development and growth. The present book, Auxin and its Role in Plant Development, provides the reader with detailed and comprehensive insight into the functioning of the molecule on...

The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in...

Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene...

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular...

Das Wort Chaos ist heute in vieler Munde. Eine Fülle von Büchern, Fernsehsendungen sowie Artikelserien befriedigt die Nachfrage einer breiten Öffentlichkeit nach Erkenntnissen der noch jungen Chaostheo­ rie. Das Verblüffende...

Die Patch-Clamp-Technik ist heute eine der wichtigsten neurophysiologischen Arbeitsmethoden. Ihre Anwendung hat in der biomedizinischen Grundlagenforschung bedeutende Erkenntnisse über die Funktion und die Eigenschaften von Ionenkanälen erbracht, und...

Lebewesen unterscheiden sich durch ihre chemische Basis. Somit ist das Wissen um die Eigenschaften der Elemente und die Wechselwirkungen der daraus entstehenden Verbindungen Voraussetzung für das Verständnis der Biologie. Die Chemie beantwortet die...

This is the first book that is not exclusively focused on ion channels functioning in sensory mechanisms that are characteristic of animals and humans, but also describes the role of ion channels in signal transduction mechanisms found in microbial cells...

This book concisely reviews our current understanding of hypoxia, molecular targeting, DNA repair, cancer stem cells, and tumor pathophysiology, while also discussing novel strategies for putting these findings into practice in daily clinical routine...

This book addresses the differentiation control of skeletal muscle in different locations of the vertebrate body Particular attention is paid to novel regulatory molecules and signals as well as the heterogeneity of origin that have revealed a...

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both...

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial...

1. 1 SCOPE OF BOOK n explosion of novel findings in the past decade has contrib­ A uted to the great progress toward understanding the biology of human cancers. Much of this progress can be attributed to our abil­ ity to...

This book constitutes the first comprehensive discussion and collection of facts and functions of unconventional secretory pathways, some of which are of importance in human disease and pathology. The function of ABC ...

The osteoclasts in Paget's disease are abnormal both in num­ ber and size and show nuclear inclusions as well as cytoplasmic inclusions that suggest a viral etiology for Paget's disease. Use of in vitro model systems for...

Atherosclerosis, the most common disease in humans and also the main cause of death in the Western world, only develops after an intima is formed. The intima is defined as the region of the arterial wall from the endothelial...

Lipid-derived molecules are increasingly appreciated as key regulators of cell responses and signal transduction. Sphingolipid-derived bioactive molecules are emerging as critical regulators of some of the most exciting and,...

This book is about the p53 gene, one of the most frequently mutated or deleted genes in human cancers. The frequent occurrence of inactivated p53 implicates this gene product in the genesis of many human cancers. The p53 gene...

The control of plant gene expression at the transcriptional level is the main subject of this volume. Genetics, molecular biology and gene technology have dramatically improved our knowledge of this event. The functional...

The first volume of the series, on "The Stability of the Differentiated State" received many favorable reviews from the scientific community. Many readers seem to agree with us that publication of topical volumes is a ...

The informational content of cells is encoded in the nucleotide sequences of their DNA. The restrictions on base pairing- A pairing with T (U), and G pairing with C - in nature assures the fidelity of replication of DNA in cell...

Chemotherapeutic Drugs and Oncogenes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 Effect of pM C540 on c-myc Oncogene in Leukemia . . . . . . . . . . . . . . . . . . . . . . . . . 188...

This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on...

The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the...

Spermatogenesis is one of the fundamental but at the same time also one of the most complex differentiation processes in higher eukaryotes. For a long time the development of spermatozoa has been considered as related solely to...

In order to survive, bacteria must constantly monitor their structure and physiology. Adaptive behaviours are established by using environmental sensors and response regulators. These communication modules regulate a wide...

Diverse alterations of glycosylation occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex rearrangements of the...

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for...

The relationship of cell lineage and differentiation is one of the most intriguing problems in developmental biology. In most higher organisms, the analysis of the cell lineage has to rely on indirect methods. Only in the most...

A Cytoplasm Connexon or Hemichannel Cytoplasm external loop I - P. M. N-Termlnus Fig. 1. 1. Topology of gap junction channels. (A) Cap junction channels, extending from the cytoplasm of one cell to the cytoplasm of another, are...

Four of the major animal systems studied for the mechanisms of their early embryonic development are treated in this volume. The articles address the specific questions studied in the various systems, discuss the fundamental ...

It is instructive to compare the response of biologists to the two themes that comprise the title of this volume. The concept of the cell cycle-in contra­ distinction to cell division-is a relatively recent one. Nevertheless...