RNA Delivery Function for Anticancer Therapeutics

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies.

• Provides　insight　into　the　current　advances　and　hurdles　of　RNAi　therapeutics.　　
• Accelerates　RNAi,　miRNAs, and siRNA　drug　development　for cancer therapy　from　bench　to　bedside.　
• Addresses　various modifications and　novel　delivery　strategies for miRNAs,　piRNAs　and siRNA delivery　in　anticancer therapeutics.　　
• Explores the need for the interaction　of　hematologists,cell　biologists,　immunologists, and material　scientists　in the development of 　novel　cancer therapies.
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• Describes the　current status　of clinical trials related to miRNA and siRNA-based cancer therapy　
• Presents　remaining issues that need to be overcome to establish　successful therapies.