This book is a leverage in understanding patch clamp technique. This book is a compilation of researches related to patch clamp technique accomplished by experts around the globe. It is basically an electrophysiological method for calculating the electric current created by a living cell. This innovative method was discovered by two professionals of Germany - Erwin Neher and Bert Sakmann. They were honored with the prestigious Nobel Prize in 1991 for their contribution to Medicine. It is even used for calculating the drug result against a sequence of diseases, and to find out the mechanism of disorders in animals and plants. It is also applied in getting the structure function actions of compounds and drugs; and major pharmaceutical firms use this method in clinical trials of their medicines. In simple words, this book deals with the theory of endogenous mechanisms of cells and its practical functions. It presents the fundamental principles and developing varieties, as well as deals with the most recent advancements in the established patch clamp method. This book intends to help students and experts in gaining more knowledge regarding this innovative technique.
This book is a leverage in understanding patch clamp technique. This book is a compilation of researches related to patch clamp technique accomplished by experts around the globe. It is basically an electrophysiological method for calculating the electric current created by a living cell. This innovative method was discovered by two professionals of Germany - Erwin Neher and Bert Sakmann. They were honored with the prestigious Nobel Prize in 1991 for their contribution to Medicine. It is even used for calculating the drug result against a sequence of diseases, and to find out the mechanism of disorders in animals and plants. It is also applied in getting the structure function actions of compounds and drugs; and major pharmaceutical firms use this method in clinical trials of their medicines. In simple words, this book deals with the theory of endogenous mechanisms of cells and its practical functions. It presents the fundamental principles and developing varieties, as well as deals with the most recent advancements in the established patch clamp method. This book intends to help students and experts in gaining more knowledge regarding this innovative technique.
Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the...
Die Patch-Clamp-Technik ist heute eine der wichtigsten neurophysiologischen Arbeitsmethoden. Ihre Anwendung hat in der biomedizinischen Grundlagenforschung bedeutende Erkenntnisse über die Funktion...
This volume describes a range of standard and novel methodological approaches used to probe ion channel function across different modalities. Chapters guide readers through methods and protocols from...
Since its inception, patch-clamp has continued to be widely considered the gold standard method to record ion channel activity. Patch-Clamp Methods and Protocols, Second Edition, provides a...
E. Neher and B. Sakman were the first to monitor the opening and closing of single ion channels and membranes by conductance measurements. In 1976, they used firepolished micropipets with a tip...
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