The ability of humans to adapt their behavior (sometimes rapidly) according to context requirements is referred to as cognitive flexibility. This flexibility is thought to be associated to a great extend with the prefrontal cortex and experimentally investigated using set shifting tasks as the Wisconsin Card Sorting Test for example. Several psychiatric and neurologic patient groups show an impaired performance in these tasks which allows to draw conclusions with respect to the neuronal base of cognitive flexibility. These are, amongst other data, usable for a neuronal modeling process. Thus, the work describes the design of a biophysical detailed neuronal model for the simulation of set shifting tasks which enables the comparison with available neuroimaging data and permits an extensive simulation of human behavior in an example experiment. Thereby a new concept behind set shifting and hence behind cognitive flexibility is illustrated which demonstrates as well the high potential of a close interaction between biophysically detailed neuronal models, computational simulations and (psychologic) experimental investigations.
The ability of humans to adapt their behavior (sometimes rapidly) according to context requirements is referred to as cognitive flexibility. This flexibility is thought to be associated to a great extend with the prefrontal cortex and experimentally investigated using set shifting tasks as the Wisconsin Card Sorting Test for example. Several psychiatric and neurologic patient groups show an impaired performance in these tasks which allows to draw conclusions with respect to the neuronal base of cognitive flexibility. These are, amongst other data, usable for a neuronal modeling process. Thus, the work describes the design of a biophysical detailed neuronal model for the simulation of set shifting tasks which enables the comparison with available neuroimaging data and permits an extensive simulation of human behavior in an example experiment. Thereby a new concept behind set shifting and hence behind cognitive flexibility is illustrated which demonstrates as well the high potential of a close interaction between biophysically detailed neuronal models, computational simulations and (psychologic) experimental investigations.
Cognitive flexibility is the cornerstone of learning and enables us to cope with a constantly changing environment. By adapting our knowledge and habits in order to respond to new situations,...
The computational paradigm considered here is a conceptual, theoretical and formal framework situated above machines and living creatures (two instant- tions), su?ciently solid, and still...
Although normally thought of as a sex hormone, recent research has highlighted the numerous and significant effects that oestrogen has on the CNS, extending far beyond its important reproductive role...
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of...
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of...
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