Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.
Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:
key interplay between transporters and enzymes in drug metabolism and drug interactions
the integral role of pharmacogenetics in metabolism-based drug-drug interactions
in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction)
in silico approaches enabling structure-activity and structure-function studies
high-throughput screening and GLP methods for evaluating drug interactions in vitro
the use of transgenic animal models to evaluate drug interactions
Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.
Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:
key interplay between transporters and enzymes in drug metabolism and drug interactions
the integral role of pharmacogenetics in metabolism-based drug-drug interactions
in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction)
in silico approaches enabling structure-activity and structure-function studies
high-throughput screening and GLP methods for evaluating drug interactions in vitro
the use of transgenic animal models to evaluate drug interactions
Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction...
Over the years a number of excellent books have classified and detailed drug drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering...
A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs,...
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