1. Neuroanatomy of dopaminergic system in the human brain.- 2. Radioligands for PET studies of D2-receptors: butyrophenone and ergot derivatives.- 3. Radioligands for dopamine receptor PET studies: benzamides and ligands for dopamine D-1 receptors.- 4. Monoamine precursors in PET research - biochemical issues and functional significance.- 5. Quantitation problems in positron emission tomography (PET) as applied to the kinetic analysis of the striatum dopamine data.- 6. Investigation of the dopamine system with positron emission tomography: general issues in modeling.- 7. Modelisation: application to the D2 receptors.- 8. [18F] Fluorodopa uptake in brain.- 9. Dopamine reuptake sites: the issues.- 10. Movement disorders: the clinical issues.- 11. Non-human primate models of dopamine system disorders: understanding neurodegenerative diseases and testing new therapeutic strategies.- 12. The dopamine system and mental disorders: clinical and psychopharmacological overview.- 13. D2 dopamine receptors and schizophrenia.- 14. The assessment of central D2-dopanvne receptor occupancy with positron emission tomography in long-term medicated schizophrenic patients.- 15. Measurement of dopamine receptor occupancy: clinical issues.
1. Neuroanatomy of dopaminergic system in the human brain.- 2. Radioligands for PET studies of D2-receptors: butyrophenone and ergot derivatives.- 3. Radioligands for dopamine receptor PET studies: benzamides and ligands for dopamine D-1 receptors.- 4. Monoamine precursors in PET research - biochemical issues and functional significance.- 5. Quantitation problems in positron emission tomography (PET) as applied to the kinetic analysis of the striatum dopamine data.- 6. Investigation of the dopamine system with positron emission tomography: general issues in modeling.- 7. Modelisation: application to the D2 receptors.- 8. [18F] Fluorodopa uptake in brain.- 9. Dopamine reuptake sites: the issues.- 10. Movement disorders: the clinical issues.- 11. Non-human primate models of dopamine system disorders: understanding neurodegenerative diseases and testing new therapeutic strategies.- 12. The dopamine system and mental disorders: clinical and psychopharmacological overview.- 13. D2 dopamine receptors and schizophrenia.- 14. The assessment of central D2-dopanvne receptor occupancy with positron emission tomography in long-term medicated schizophrenic patients.- 15. Measurement of dopamine receptor occupancy: clinical issues.
This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving...
This volume provides a variety of technical approaches to study dopamine system function and dysfunction. Chapters guide readers through dopamine release in ex vivo and freely moving...
Parkinson's disease, a degenerative brain disorder, affects an estimated 0.25-0.50% of the population. Symptoms result from neuronal degeneration in the nigrostriatal dopaminergic pathway and include...
This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and...
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