The Adrenergic Receptors

Part I: Historical Perspectives Adrenergic Receptors: Historical Perspectives From the 20th Century David B. Bylund Part II: Structure-Function Ligand Binding, Activation, and Agonist Trafficking Angela M. Finch, Valerie Sarramegna, and Robert M. Graham New Signal Transduction Paradigms Kenneth P. Minneman Regulation of the Cellular Localization and Trafficking of the Adrenergic Receptors Michael T. Piascik, Mary Lolis García-Cazarin, and Steven R. Post Adrenergic Receptors in Clinical Medicine Martin C. Michel and Paul A. Insel Part III: Imaging Adrenergic Receptors and Their Function Use of Fluorescent Ligands and Receptors to Visualize Adrenergic Receptors John C. McGrath and Craig J. Daly Localization of Adrenergic Receptor Subtypes and Transgenic Expression of Fluorescent-Tagged Receptors Dianne M. Perez Part IV: Genetically Altered Mouse Models The a1-Adrenergic Receptors: Lessons From Knockout Paul C. Simpson The a2-Adrenergic Receptors: Lessons From Knockouts Christopher M. Tan and Lee E. Limbird The b-Adrenergic Receptors: Lessons From Knockouts Yang Xiang and Brian Kobilka Lessons From Overexpressed Mouse Models Cinzia Perrino, Liza Barki-Harrington, and Howard A. Rockman Adrenergic Receptor Signaling Components in Gene Therapy Andrea D. Eckhart and Walter J. Koch Part V: Pharmacogenomics Genetic, Molecular, and Clinical Characterization of Adrenergic Receptor Polymorphisms Stephen B. Liggett Microarray Analysis of Novel Adrenergic Receptor Functions Boyd Rorabaugh, June Yun, and Dianne M. Perez Part VI: Summary and Future Endeavors Summary and Future Endeavors Dianne M. Perez Index