1. Stem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the "Proclinical Space"
Gary Gintant and Stefan Braam
2. Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk
Sei Kameoka and Eric Chiao
3. Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology
Muthukrishnan Renganathan, Haiyang Wei, and Yong Zhao
4. Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes
Alison Obergrussberger, Claudia Haarmann, Sonja Stölzle-Feix, Nadine Becker, Atsushi Ohtsuki, Andrea Brüggemann, Michael George, and Niels Fertig
5. The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential
Daniel C. Millard, Mike Clements, and James D. Ross
6. Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions
Graham T. Dempsey and Christopher A. Werley
7. HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems
Ralf Kettenhofen
8. Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes
Emily R. Pfeiffer, Ross Whittaker, Raquel Vega, Fabio Cerignoli, Patrick M. McDonough, and Jeffrey H. Price
9. Decoding Ca2+ Signals as a Non-Electrophysiological Method for Assessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes
Christopher H. George and David H. Edwards
10. Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes
Alison Obergrussberger, Ulrich Thomas, Sonja Stölzle-Feix, Nadine Becker, Krisztina Juhasz; Leo Doerr, Matthias Beckler, Michael George, and Niels Fertig
11. Edge Detection for Contractility Measurements with Cardiac Spheroids
Christian Zuppinger
12. Contractile Force Readout of hESC-Cardiomyocytes
Carlota Oleaga, Gregg Legters, L. Richard Bridges, Lee Kumanchik, Candace Martin, Yunqing Cai, Mark Schnepper, Christopher W. McAleer, Christopher J. Long, and James J. Hickman
13. In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models
Liz Roquemore, Ariel Kauss, Catherine Hather, Nick Thomas, and Hirdesh Uppal
14. Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Janos Kriston-Vizi, Sian E. Harding, and Gábor Földes
15. Addressing Fun
