This thesis studies wet granulation on threedifferent levels. First, micro-level investigationsof liquid bridges between two and three particles areperformed. For the two-particle case, the fluidprofile of static (stationary) and dynamic (moving)liquid bridges are investigated. Static liquidbridges between three equally sized primary particlesare then studied; the symmetry of the problem is usedto obtain a numerical solution to the Young-Laplaceequation. Secondly, a model to estimate thestickiness (fractional wet surface area) ofagglomerates is proposed. The model includesparameters to control the inter-particle separationdistance and the fluid saturation state.Computational geometry is used to obtain resultswhich relate the number of particles and the volumeof binder fluid to the stickiness of theagglomerates. Finally, a population balance model forwet granulation is developed by extending an earliermodel to incorporate the effects of binder fluid. Themodel is solved numerically for a range ofcoalescence kernels and results are presented whichshow the effect of binder volume and the drying rate.
This thesis studies wet granulation on threedifferent levels. First, micro-level investigationsof liquid bridges between two and three particles areperformed. For the two-particle case, the fluidprofile of static (stationary) and dynamic (moving)liquid bridges are investigated. Static liquidbridges between three equally sized primary particlesare then studied; the symmetry of the problem is usedto obtain a numerical solution to the Young-Laplaceequation. Secondly, a model to estimate thestickiness (fractional wet surface area) ofagglomerates is proposed. The model includesparameters to control the inter-particle separationdistance and the fluid saturation state.Computational geometry is used to obtain resultswhich relate the number of particles and the volumeof binder fluid to the stickiness of theagglomerates. Finally, a population balance model forwet granulation is developed by extending an earliermodel to incorporate the effects of binder fluid. Themodel is solved numerically for a range ofcoalescence kernels and results are presented whichshow the effect of binder volume and the drying rate.
This book had its origins in a meeting between two (relatively) young particle technology researchers on Rehobeth Beach in Delaware in 1992 near the holiday house of Reg Davies (then Director of the...
Many approaches have already been proposed for classification and modeling in the literature. These approaches are usually based on mathematical mod els. Computer systems can easily handle...
Polymers are substances made of macromolecules formed by thousands of atoms organized in one (homopolymers) or more (copolymers) groups that repeat themselves to form linear or branched chains, or...
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