For the last decade or so, in vitro toxicology has been studied as a method for determining human toxicity, as well as hazard identification and characterization. One purpose of in vitro studies is to determine the possibility of developing systems in which the toxicity of chemicals can be quantified, without heavy reliance on animal experimentation. Specific data pertaining to cadmium toxicity in humans through use of in vitro methods and models is sparse, at best. There is a need to complete more studies and collect more data to study particular chemicals and their effects and to complete proper evaluation and comparison to in vitro studies on human cells. The need for such data is the overall reason for this thesis research and experimentation. Toxicology in vitro refers to a method of exposing cell tissue directly to the chemical compound under study. In this research, rat liver cells, or hepatocytes, were cultured, exposed to cadmium oxide particles, and analyzed with an MTT assay. Experiments were carried out with doses ranging from 0.001 ??g/mL to 2.5 ??/mL for 6, 12, and 24 hours. Two cell densities were also studied for each experiment, 1,000,000 cells/mL and 500,000 cells/mL, in order to ascertain the effects of toxicity on cell density. The research led to the conclusion 1,000,000 cells/mL is more resistant to the toxicant than 500,000 cells/mL and the toxicant is most toxic to the cells after 24 hours.
In Vitro Toxicity of Cadmium Oxide Particles in BRL 3A Rat Liver Cells
RRP:
$97.00
Description
For the last decade or so, in vitro toxicology has been studied as a method for determining human toxicity, as well as hazard identification and characterization. One purpose of in vitro studies is to determine the possibility of developing systems in which the toxicity of chemicals can be quantified, without heavy reliance on animal experimentation. Specific data pertaining to cadmium toxicity in humans through use of in vitro methods and models is sparse, at best. There is a need to complete more studies and collect more data to study particular chemicals and their effects and to complete proper evaluation and comparison to in vitro studies on human cells. The need for such data is the overall reason for this thesis research and experimentation. Toxicology in vitro refers to a method of exposing cell tissue directly to the chemical compound under study. In this research, rat liver cells, or hepatocytes, were cultured, exposed to cadmium oxide particles, and analyzed with an MTT assay. Experiments were carried out with doses ranging from 0.001 ??g/mL to 2.5 ??/mL for 6, 12, and 24 hours. Two cell densities were also studied for each experiment, 1,000,000 cells/mL and 500,000 cells/mL, in order to ascertain the effects of toxicity on cell density. The research led to the conclusion 1,000,000 cells/mL is more resistant to the toxicant than 500,000 cells/mL and the toxicant is most toxic to the cells after 24 hours.
Nanomaterials, which are by definition in the 1 - 100 nanometer range, have numerous possible benefits to society, but currently there is a lack of data that characterizes these materials effects on...
Nanotechnology is a thriving industry and has the potential to benefit society in numerous ways. However, not all environmental and human health concerns of nanomaterials have been addressed. Thus,...
Nanotechnology is quickly becoming incorporated into everyday products and uses. Silver nanoparticles, specifically, are being used in commercial products, to include aerosols. The purpose of this...
This scientific monograph presents a detailed investigation of the higher oxides of zinc and cadmium, and their applications in pigments, catalysts, and other industrial products. A valuable resource...
In vitro toxicology is one of the most rapidly expanding areas of biological research today. It is generally conceded that this is a result of pressure from the public for safer products and...
Discover your next great read at BookLoop, Australiand online bookstore offering a vast selection of titles across various genres and interests. Whether you're curious about what's trending or searching for graphic novels that captivate, thrilling crime and mystery fiction, or exhilarating action and adventure stories, our curated collections have something for every reader. Delve into imaginative fantasy worlds or explore the realms of science fiction that challenge the boundaries of reality. Fans of contemporary narratives will find compelling stories in our contemporary fiction section. Embark on epic journeys with our fantasy and science fiction titles,
Shop Trending Books and New Releases
Explore our new releases for the most recent additions in romance books, fantasy books, graphic novels, crime and mystery books, science fiction books as well as biographies, cookbooks, self help books, tarot cards, fortunetelling and much more. With titles covering current trends, booktok and bookstagram recommendations, and emerging authors, BookLoop remains your go-to local australian bookstore for buying books online across all book genres.
Shop Best Books By Collection
Stay updated with the literary world by browsing our trending books, featuring the latest bestsellers and critically acclaimed works. Explore titles from popular brands like Minecraft, Pokemon, Star Wars, Bluey, Lonely Planet, ABIA award winners, Peppa Pig, and our specialised collection of ADHD books. At BookLoop, we are committed to providing a diverse and enriching reading experience for all.
Buy Educational Books and Textbooks Online at BookLoop
Shop School Textbooks for Primary, Secondary, and Higher Education
At BookLoop, we make it easy to buy school textbooks online in Australia for every stage of learning. Our extensive
textbook collection includes curriculum-aligned primary school books,
secondary school books, and resources for TAFE courses, vocational training, and university studies.
Each title is selected for accuracy, quality, and alignment with the Australian Curriculum, supporting teachers, students, and schools across the country. Whether you’re preparing for exams, classroom learning, or distance education, BookLoop’s range of educational books ensures your students have the right materials to succeed.
Teacher Resources, Classroom Tools and Professional Learning
Empower your teaching with teacher resources and classroom support materials from BookLoop.
Our collection includes lesson planning guides, literacy and numeracy workbooks, STEM education resources, and assessment tools that help educators deliver engaging, effective learning experiences.
We also stock a wide selection of preschool and early years education books tailored to early childhood development, classroom management, and student wellbeing.
Teachers can access everything from professional development books to interactive classroom activities — all carefully curated to enhance teaching outcomes and student success.
Educational Books and Learning Resources for Every Subject
Find educational books for students across a variety of subjects including English, Mathematics, Science, History, Geography, and the Arts.
BookLoop partners with trusted Australian publishers to provide up-to-date resources that meet classroom requirements and support independent learning.
Whether you’re a school administrator sourcing bulk textbook orders, a parent preparing for the new term, or a teacher updating your classroom library, BookLoop is your one-stop online bookstore for all education and teaching materials.
Sign In
your cart
Your cart is empty
Menu
Search
PRE-SALES
If you have any questions before making a purchase chat with our online operators to get more information.
