The human leukocyte antigens are genetically inherited proteins present on the surface of the cells of the immune system. Cells of the immune system recognize antigens only when presented to them next to an MHC self-molecule. Three main types of HLA Class I namely, HLA-A, HLA-B and HLA-C they are expressed by most human cells. Class I HLAs are involved in discriminating and presenting antigens to T-lymphocytes. T-lymphocytes kill the cell presenting it. T-lymphocytes destroy cells infected together with viruses, including HIV. Developing a vaccine for HIV may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B57 or HLA-B27, these alleles remain the most robust associations with low concentrations of plasma virus.
Human Leukocyte HLA-B7 and HLA-B27 Antigen Typing Among Healthy Adults
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Description
The human leukocyte antigens are genetically inherited proteins present on the surface of the cells of the immune system. Cells of the immune system recognize antigens only when presented to them next to an MHC self-molecule. Three main types of HLA Class I namely, HLA-A, HLA-B and HLA-C they are expressed by most human cells. Class I HLAs are involved in discriminating and presenting antigens to T-lymphocytes. T-lymphocytes kill the cell presenting it. T-lymphocytes destroy cells infected together with viruses, including HIV. Developing a vaccine for HIV may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B57 or HLA-B27, these alleles remain the most robust associations with low concentrations of plasma virus.
This edition provides a collection of state-of-art methods and tools for human leukocyte antigen (HLA) and major histocompatibility complex (MHC) research. The book explores updated as well as novel...
This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and...
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