The response of (laboratory) animals to anaestheticsand analgesics shows intraspecies variability. Besides environmental influences, genetic factors might be involved in this phenomenon. In the studies described in this book, rabbit and rat inbred strains were used to identify differences in response to anaesthetics and analgesics. Parameters for a genetic analysis were thus provided to identify candidate genes involved in this variability. Both in the rat and rabbit,significant strain differences were observed in the response to a variety of commonly used anaesthetics and analgesics in (laboratory animal) medicine. The difference in response to medetomidine between two rabbit strains was linked to differences in the anaesthetic's biotransformation rate. This response was then genetically analyzed and candidate genes were identified on the rabbit genetic map. In the rats it was demonstrated that buprenorphine administration did not only result in strain-specificresponses to its analgesic but also to its behavioural effects. This book will aid medical and veterinary researchers in the development of tailored anaesthesia.
Genetic background and the response to anaesthetics and analgesics
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The response of (laboratory) animals to anaestheticsand analgesics shows intraspecies variability. Besides environmental influences, genetic factors might be involved in this phenomenon. In the studies described in this book, rabbit and rat inbred strains were used to identify differences in response to anaesthetics and analgesics. Parameters for a genetic analysis were thus provided to identify candidate genes involved in this variability. Both in the rat and rabbit,significant strain differences were observed in the response to a variety of commonly used anaesthetics and analgesics in (laboratory animal) medicine. The difference in response to medetomidine between two rabbit strains was linked to differences in the anaesthetic's biotransformation rate. This response was then genetically analyzed and candidate genes were identified on the rabbit genetic map. In the rats it was demonstrated that buprenorphine administration did not only result in strain-specificresponses to its analgesic but also to its behavioural effects. This book will aid medical and veterinary researchers in the development of tailored anaesthesia.
Medical Responsibility in the Choice of Anaesthetics is an unchanged, high-quality reprint of the original edition of 1876.Hansebooks is editor of the literature on different topic areas such as...
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and...
The "Genetics, Man, and Society" symposium was a collaborative effort of the Task Force on Genetics and Reproduction at Yale University and the Youth Council of the American Association for the...
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and...
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