Communication between cells via intercellular channels - gap junctions - appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.
Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Communication between cells via intercellular channels - gap junctions - appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed.
Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.
Presentingstate-of-the-art protocols to study gap junctions, this detailed book firstfocuses on the use of methods and tools to investigate the different aspects ofconnexin expression and gap...
Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. Pannexin channels are a family of closely related large-pore...
A Cytoplasm Connexon or Hemichannel Cytoplasm external loop I - P. M. N-Termlnus Fig. 1. 1. Topology of gap junction channels. (A) Cap junction channels, extending from the cytoplasm of one cell to...
This dedicated volume in the series Advances and Technical Standards in Neurosurgery (ATSN) provides a comprehensive approach to diseases of the craniovertebral junction (CVJ) and their management...
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