To obtain an enhanced in-vitro dissolution rate of simvastatin by using Liquisolid technique and Liquisolid tablets were optimized by DoE approach 32 full factorial design using Design Expert Software.The liquisolid tablets were formulated by using propylene glycol (PG), as liquid vehicle, Avicel PH-102 as a carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant. The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems and to calculate amount of carrier material and coating material.Simvasatin Liquisolid compacts enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be useful to formulate fast disintegrating Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.
To obtain an enhanced in-vitro dissolution rate of simvastatin by using Liquisolid technique and Liquisolid tablets were optimized by DoE approach 32 full factorial design using Design Expert Software.The liquisolid tablets were formulated by using propylene glycol (PG), as liquid vehicle, Avicel PH-102 as a carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant. The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems and to calculate amount of carrier material and coating material.Simvasatin Liquisolid compacts enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be useful to formulate fast disintegrating Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.
The objective of this research work was to formulate and evaluate the floating drug delivery system containing Albendazole, an anthelmintic drug, using different polymers and to optimize the best...
Amlodipine used as an anti-hypertensive and in the treatment of angina. FDT of amlodipine besylate were prepared using different superdisintegrants by direct compression method. Mannitol was used as...
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble...
The present investigation involves formulation and evaluation of fast dissolving tablet of clopidogrel, which is used to prevent coronary disorder. Platelet aggregation is part of the sequence events...
The data obtained from the study of, "Formulation and Evaluation of hydrogel containing antimicrobial drug (Azithromycin) and silver nanoparticles" reveals that Silver nanoparticles were reported to...
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