This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer. Issues related to the mutagenicity of 5-methylcytosine and the increase in the interaction of chemical and physical carcinogens with these residues is discussed. The book summarizes the modulation of viral gene expression and the silencing of tumor suppressor genes and illustrates mechanisms by which the methylation signal is translated into altered chromatin structure. The relationship between DNA methylation and genomic imprinting and cancer, and changes in CpG island methylation which occur in aging are discussed. Mouse model systems have played a key role in our dissection of the relationship between methylation and cancer, and these are also portrayed together with descriptions of new clinical trials in which methylation inhibitors are being used to treat leukemia, myeloid dysplastic syndromes and hemoglobinopathies.
This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer. Issues related to the mutagenicity of 5-methylcytosine and the increase in the interaction of chemical and physical carcinogens with these residues is discussed. The book summarizes the modulation of viral gene expression and the silencing of tumor suppressor genes and illustrates mechanisms by which the methylation signal is translated into altered chromatin structure. The relationship between DNA methylation and genomic imprinting and cancer, and changes in CpG island methylation which occur in aging are discussed. Mouse model systems have played a key role in our dissection of the relationship between methylation and cancer, and these are also portrayed together with descriptions of new clinical trials in which methylation inhibitors are being used to treat leukemia, myeloid dysplastic syndromes and hemoglobinopathies.
Preface ................................................................................................ xiii 1. DNA Methylation: Three Decades in Search of Function ...................... 1 Aharon...
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the...
This book presents an elucidative account on the mechanisms and fundamental concepts of DNA Methylation. Alterations in the normal DNA methylation processes can inflict serious results on embryonic...
Postreplicative methylation of bacterial DNA has long been known to be the molecular basis of" modification," which protects DNA against destruction by restriction endonucleases. More recently,...
This book aims to educate readers about the concepts of DNA methylation. Epigenetics is one of the most thrilling and speedily increasing areas of modern genetics with functions in many disciplines...
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