Interest in a vaccine for dental caries prevention dates back to a period when the lactobacilli were thought to be of paramount importance in the initiation of dental caries. By means of immunization with a homologous lactobacillus vaccine, in 1944 William was partially successful in reducing the number of lactobacilli in human saliva. More recently, the understanding of the important role that streptococcus mutans plays in the initiation of caries has a re-awakening of interest in the vaccine approach, as evidenced by the numerous experimental attempts to control caries immunologically in laboratory animals such as rats and monkeys. Although results have not always been encouraging, the development of a caries vaccine is considered a highly desirable goal because of the potential important public health implications. Though the research on the caries vaccine started in 1930, much attention has been given to it only in the last three decades. Since then, many new vaccines have been developed and continued research in this field has also disclosed the potential drawbacks.
Interest in a vaccine for dental caries prevention dates back to a period when the lactobacilli were thought to be of paramount importance in the initiation of dental caries. By means of immunization with a homologous lactobacillus vaccine, in 1944 William was partially successful in reducing the number of lactobacilli in human saliva. More recently, the understanding of the important role that streptococcus mutans plays in the initiation of caries has a re-awakening of interest in the vaccine approach, as evidenced by the numerous experimental attempts to control caries immunologically in laboratory animals such as rats and monkeys. Although results have not always been encouraging, the development of a caries vaccine is considered a highly desirable goal because of the potential important public health implications. Though the research on the caries vaccine started in 1930, much attention has been given to it only in the last three decades. Since then, many new vaccines have been developed and continued research in this field has also disclosed the potential drawbacks.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of...
Theodor Leber's book provides an overview of dental caries and its causes. It offers a detailed analysis of the pathology of dental caries and its treatment.This work has been selected by scholars as...
Dental caries is a chronic disease among humans and is a major global oral health problem in the world today. Caries is the demineralisation of dental tissue through acid produced by bacterial...
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