This book entitled "Apoptotic studies and phytochemical analyses in the suicide tree, Cerbera odollam Gaertn. (Apocynaceae)" reveals the apoptotic and phytochemical efficacy of a potential medicinal plant. C. odollam is native to India and other parts of southern Asia. The suicide plant, C. odollam has got kernels that contain a digoxin type cardenolide and cardiac toxin Cerberin that blocks the calcium ion channels in heart muscle, disrupting the heartbeat, which may be fatal if consumed. The aqueous solutions of the leaf extracts were assessed for the existence of potential phytochemical constituents. Quantitative preliminary phytochemical analysis was done to reveal total phenolic, flavonoid, terpenoid, and alkaloid content. Cytotoxic studies were carried out using Allium cepa root tip assay and the cell death was determined by Evans blue stain both macroscopically and spectrophotometrically. Cellular abnormalities like induction of binucleate cells, apoptotic fragmentation, ghost cell, giant cell, membrane blebs, sticky metaphase, etc. were observed during cytotoxic evaluation. The study reveals the significant apoptotic/cytotoxic activities of aqueous extracts of C. odollam.
Apoptotic studies and phytochemical analyses in the suicide tree
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This book entitled "Apoptotic studies and phytochemical analyses in the suicide tree, Cerbera odollam Gaertn. (Apocynaceae)" reveals the apoptotic and phytochemical efficacy of a potential medicinal plant. C. odollam is native to India and other parts of southern Asia. The suicide plant, C. odollam has got kernels that contain a digoxin type cardenolide and cardiac toxin Cerberin that blocks the calcium ion channels in heart muscle, disrupting the heartbeat, which may be fatal if consumed. The aqueous solutions of the leaf extracts were assessed for the existence of potential phytochemical constituents. Quantitative preliminary phytochemical analysis was done to reveal total phenolic, flavonoid, terpenoid, and alkaloid content. Cytotoxic studies were carried out using Allium cepa root tip assay and the cell death was determined by Evans blue stain both macroscopically and spectrophotometrically. Cellular abnormalities like induction of binucleate cells, apoptotic fragmentation, ghost cell, giant cell, membrane blebs, sticky metaphase, etc. were observed during cytotoxic evaluation. The study reveals the significant apoptotic/cytotoxic activities of aqueous extracts of C. odollam.
This book systematically presents and classifies the latest advances in suicide research in contemporary China, examines the status quo of suicides in China and analyzes the reasons for suicides...
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it.This work is in the "public domain in the United States of...
This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role...
This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it.This work is in the public domain in the United States of...
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