Antiepileptic Drug Discovery

Part I: Novel Approaches for the Treatment of Epilepsy

1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy

            María-Leonor López-Meraz, Jesús-Servando Medel-Matus, and Jerome Niquet

2. The Use of Anti-Inflammatory Drugs in Epilepsy

            María Guadalupe Valle-Dorado, Laura Elena Córdova-Dávalos, Daniel Pérez-Pérez, Rosalinda Guevara-Guzmán, and Luisa Rocha

3. Carbonic Anhydrase and Epilepsy

            Luciana Gavernet

4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs

            Luz Adriana Pichardo-Macías, Itzel Jatziri Contreras-García, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca

5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?

            Cecilia Zavala-Tecuapetla and Luisa Rocha

6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy

            Manola Cuellar-Herrera, César E. Santana-Gómez, Francia Carmona-Cruz, Daruni Vázquez-Barrón, Francisco Velasco, and Ana L. Velasco

7. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity

            Suchitra Joshi and Jaideep Kapur

8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy

            Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski

9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery

            Karla G. Carvajal Aguilera and Bryan V. Phillips Farfán

10. Gene Therapy in Epilepsy

            Miguel A. López-García, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez

Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy

11. Human Brain Tissue as a Model for the Study of Epilepsy

            Leonardo Lara-Valderrábano, Ivette Bañuelos-Cabrera, Víctor Navarrete-Modesto, and Luisa Rocha

12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs

            Gabriela Rogel-Salazar and Hiram Luna-Munguia

13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates

            Alan Talevi and Luis E. Bruno-Blanch

14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations

            Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch

15. Discovering New Antiepileptic Drugs Addressing the Transp