Apoptosis, induced in cancer cells by antitumor agents such as doxorubicin, dactinomycin, and the platinum drugs, is characterized by impaired respiration, decreased ATP, and activated caspase. To investigate the sensitivity of malignant cells to a variety of drug agents, quantitative measures of cytotoxicity under treatment of those drugs are employed. The mitochondrial oxygen consumptions are monitored by analyzing the phosphorescence decay rate of a palladium phosphor. Simultaneously, cellular ATP contents are detected through a bioluminescence system, and intracellular caspase activation measured by adopting the fluorogenic substrate. Comparing the ways in which respiration, ATP level, and caspase activity vary with time points up differences between the mechanisms of actions of various drugs, which finally result in mitochondrial dysfunction and cell apoptosis. These results become very useful in choosing the most effective drug for a particular clinical application.
Apoptosis, induced in cancer cells by antitumor agents such as doxorubicin, dactinomycin, and the platinum drugs, is characterized by impaired respiration, decreased ATP, and activated caspase. To investigate the sensitivity of malignant cells to a variety of drug agents, quantitative measures of cytotoxicity under treatment of those drugs are employed. The mitochondrial oxygen consumptions are monitored by analyzing the phosphorescence decay rate of a palladium phosphor. Simultaneously, cellular ATP contents are detected through a bioluminescence system, and intracellular caspase activation measured by adopting the fluorogenic substrate. Comparing the ways in which respiration, ATP level, and caspase activity vary with time points up differences between the mechanisms of actions of various drugs, which finally result in mitochondrial dysfunction and cell apoptosis. These results become very useful in choosing the most effective drug for a particular clinical application.
The focus of the 22nd Annual Detroit Cancer Symposium was the presentation and discussion of cytotoxic agents, with a significant portion of the symposium including the exciting frontiers of drug ...
The past decades have seen major developments in the understanding of the cellular and molecular biology of cancer. Significant progress has been achieved regarding long-term survival for the...
Since cytotoxic drugs were first developed, their damaging effects on bone marrow have attracted considerable interest. We now know that the bone marrow is an organ with rapid cell renewal in which...
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