1: Molecular Biology.- Structure and Function of the Human Poly(ADP-Ribose) Polymerase.- Cloning of Poly(ADP-Ribose) Polymerase cDNA from Lower Eukaryotes.- Molecular Biology of Human Nuclear NAD+: ADP-Ribosyl-transferase (Polymerizing).- Strategies for Studying the Functions of PADPRP Genes on Human Chromosomes 1 and 13.- Expression of the DNA-Binding Domain of Human Poly(ADP-Ribose) Polymerase as a Trans-Dominant Inhibitor of Poly(ADP-Ribosyl)ation in Transfected Eucaryotic Cell Lines.- Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-Ribose) Polymerase.- Chicken Poly(ADP-Ribose) Polymerase. Complete Protein Sequence Deduced from cDNA, Comparison with Mammalian Enzyme Sequences.- Nuclear Poly(ADPR) Polymerase Expression and Activity in Rat Astrocytes Culture: Effects of bFGF.- Molecular Cloning of the Rat Poly(ADP-Ribose) Polymerase Gene and Preliminary Characterization of its Promoter and 5'-Flanking Regions.- Structure and Organization of the Mouse pADPRT Gene.- Strategies for Expressing Analogs of PADPRP in Eukaryotic Cells.- Expression and Characterization of PADPRP and a Novel Glucocorticoid-PADPRP "Finger Swapped" Protein from Escherichia coil.- Tumor Promoters, But Not EGF, Increase Nuclear Poly(ADP-Ribose) Polymerase Gene Expression in Rat Hepatocytes Initiated in Utero with DMN and Cultured After Birth in Low-Calcium Synthetic Medium.- Expression of the Gene for Poly(ADP-Ribose) Polymerase and DNA Polymerase ß in Rat Tissues and in Proliferating Cells.- Expression of Poly(ADP-Ribose) Polymerase in Differentiating HL-60 Cells..- 2: Cancer, DNA Repair, and Metabolism.- A Novel Model of Enzymatic Repair of U.V.-Induced DNA Damage in Human Cells.- Poly(ADP-Ribose) Polymerase in Xenopus Laevis.- ADP-Ribosylation is Involved in the Integration of Exogenous DNA into the Mammalian Cell Genome, but is not Required for the Episomal Replication or Expression of Autonomously Replicating Plasmids.- Inhibitors of Poly(ADP-Ribose) Polymerase Block the Infection of Mammalian Cells by Retroviral Vectors.- Detection and Analysis of NAD Binding Proteins Including Poly(ADP-Ribose) Polymerase Immobilized on the Membrane.- An In Vitro Replication System for Autonomously Replicating Mammalian Origin-Enriched Sequences.- Variation in Poly(ADP-Ribose) Polymerase Activity and 2', 5'-Oligoadenylates Core Concentration in Estrogen-Stimulated Uterus and Liver of Immature and Adult Rats.- Possible Involvement of Poly(ADP-Ribose) Polymerase in the Brain Function.- Inhibition of Interferon-?-Dependent Induction of Major Histocompatibility Complex Class II Antigen by Expressing Exogenous Poly(ADP-Ribose) Synthetase Gene.- ADP-Ribose Polymers Bind Specifically and Non-covalently to Histones.- Poly(3'-deoxy ADP-ribosyl)ation of Proteins in Liver Chromatin Isolated from Rats Fed with Hepatocarcinogens.- ADP-Ribose Polymer Metabolism: Implications for Human Nutrition.- Some Aspects of Nuclear and Cytoplasmic ADP-ribosylation. Biological and Pharmacological Perspectives.- DNA Base Excision Repair Stimulates Poly(ADP-Ribose) Synthesis.- Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity.- DNA Topoisomerase I and Poly(ADP-Ribose) Polymerase in the Early Stages of Hepatocarcinogenesis.- Poly(ADP-Ribose) Polymerase Inhibitors Induce Murine Melanoma Cell Differentiation by a Mechanism Independent of Alterations in cAMP Levels and Protein Kinase A Activity.- Enhancement of Antimetabolite Cytoatoxicity by 3-Aminobenzamide in Chinese Hamster Ovary Cells is Independent of Poly(ADP-Ribose) Polymerase Inhibition.- Evidence for the Participation of Poly(ADP-Ribosyl)ation in Collagenase Gene Expression in Rabbit Synovial Fibroblasts after Treatment with Active Oxygen Released by Xantbin/Xanthinoxidase.- Enhancement of Oncogene-Mediated Transformation in Cloned Rat Embryo Fibroblast (CREF) Cells by 3-Anilnobenzamide.- Control of Procollagen Gene Transcription and Prolyl Hydroxylase Activity by Poly(ADP-Ribose).- Poly(ADP-Ribose) Synt
1: Molecular Biology.- Structure and Function of the Human Poly(ADP-Ribose) Polymerase.- Cloning of Poly(ADP-Ribose) Polymerase cDNA from Lower Eukaryotes.- Molecular Biology of Human Nuclear NAD+: ADP-Ribosyl-transferase (Polymerizing).- Strategies for Studying the Functions of PADPRP Genes on Human Chromosomes 1 and 13.- Expression of the DNA-Binding Domain of Human Poly(ADP-Ribose) Polymerase as a Trans-Dominant Inhibitor of Poly(ADP-Ribosyl)ation in Transfected Eucaryotic Cell Lines.- Directed Mutagenesis of Glutamic Acid 988 of Poly(ADP-Ribose) Polymerase.- Chicken Poly(ADP-Ribose) Polymerase. Complete Protein Sequence Deduced from cDNA, Comparison with Mammalian Enzyme Sequences.- Nuclear Poly(ADPR) Polymerase Expression and Activity in Rat Astrocytes Culture: Effects of bFGF.- Molecular Cloning of the Rat Poly(ADP-Ribose) Polymerase Gene and Preliminary Characterization of its Promoter and 5'-Flanking Regions.- Structure and Organization of the Mouse pADPRT Gene.- Strategies for Expressing Analogs of PADPRP in Eukaryotic Cells.- Expression and Characterization of PADPRP and a Novel Glucocorticoid-PADPRP "Finger Swapped" Protein from Escherichia coil.- Tumor Promoters, But Not EGF, Increase Nuclear Poly(ADP-Ribose) Polymerase Gene Expression in Rat Hepatocytes Initiated in Utero with DMN and Cultured After Birth in Low-Calcium Synthetic Medium.- Expression of the Gene for Poly(ADP-Ribose) Polymerase and DNA Polymerase ß in Rat Tissues and in Proliferating Cells.- Expression of Poly(ADP-Ribose) Polymerase in Differentiating HL-60 Cells..- 2: Cancer, DNA Repair, and Metabolism.- A Novel Model of Enzymatic Repair of U.V.-Induced DNA Damage in Human Cells.- Poly(ADP-Ribose) Polymerase in Xenopus Laevis.- ADP-Ribosylation is Involved in the Integration of Exogenous DNA into the Mammalian Cell Genome, but is not Required for the Episomal Replication or Expression of Autonomously Replicating Plasmids.- Inhibitors of Poly(ADP-Ribose) Polymerase Block the Infection of Mammalian Cells by Retroviral Vectors.- Detection and Analysis of NAD Binding Proteins Including Poly(ADP-Ribose) Polymerase Immobilized on the Membrane.- An In Vitro Replication System for Autonomously Replicating Mammalian Origin-Enriched Sequences.- Variation in Poly(ADP-Ribose) Polymerase Activity and 2', 5'-Oligoadenylates Core Concentration in Estrogen-Stimulated Uterus and Liver of Immature and Adult Rats.- Possible Involvement of Poly(ADP-Ribose) Polymerase in the Brain Function.- Inhibition of Interferon-?-Dependent Induction of Major Histocompatibility Complex Class II Antigen by Expressing Exogenous Poly(ADP-Ribose) Synthetase Gene.- ADP-Ribose Polymers Bind Specifically and Non-covalently to Histones.- Poly(3'-deoxy ADP-ribosyl)ation of Proteins in Liver Chromatin Isolated from Rats Fed with Hepatocarcinogens.- ADP-Ribose Polymer Metabolism: Implications for Human Nutrition.- Some Aspects of Nuclear and Cytoplasmic ADP-ribosylation. Biological and Pharmacological Perspectives.- DNA Base Excision Repair Stimulates Poly(ADP-Ribose) Synthesis.- Studies on Poly(ADP-Ribosyl)ation in DNA Amplification and Mammalian Longevity.- DNA Topoisomerase I and Poly(ADP-Ribose) Polymerase in the Early Stages of Hepatocarcinogenesis.- Poly(ADP-Ribose) Polymerase Inhibitors Induce Murine Melanoma Cell Differentiation by a Mechanism Independent of Alterations in cAMP Levels and Protein Kinase A Activity.- Enhancement of Antimetabolite Cytoatoxicity by 3-Aminobenzamide in Chinese Hamster Ovary Cells is Independent of Poly(ADP-Ribose) Polymerase Inhibition.- Evidence for the Participation of Poly(ADP-Ribosyl)ation in Collagenase Gene Expression in Rabbit Synovial Fibroblasts after Treatment with Active Oxygen Released by Xantbin/Xanthinoxidase.- Enhancement of Oncogene-Mediated Transformation in Cloned Rat Embryo Fibroblast (CREF) Cells by 3-Anilnobenzamide.- Control of Procollagen Gene Transcription and Prolyl Hydroxylase Activity by Poly(ADP-Ribose).- Poly(ADP-Ribose) Synt
ADP-ribosylating toxins have been the focus of intensive research for more than 30 years. Researchers from diverse fields of science have taken an interest in these bacterial toxins; they are...
In 1966, a paper entitled "On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly...
Introduction. Mono(ADP-ribosyl)Transferases and Related Enzymes: Emerging Gene Families; F. Koch-Nolte, F. Haag. Mono-ADP-ribosylation in Prokaryotes. Crystal Structure of Diphtheria Toxin Bound...
The U.S. Government Accountability Office (GAO) is an independent agency that works for Congress. The GAO watches over Congress, and investigates how the federal government spends taxpayers dollars...
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