This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.
The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.
Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec
ts of the networks themselves to the balance of biochemical fluxes.
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures.
The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions.
Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec
ts of the networks themselves to the balance of biochemical fluxes.
A global research community of scientists is studying the biochemical mechanisms that manage regular cellular physiology in various organisms. A great deal of ongoing research focuses on...
A widespread appreciation for the role that calcium plays in cell physiology and patho physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth...
The NATO Advanced Research Workshop on nThe Organization of Cell n Metabolism was held 31 August - 4 September, 1985, at the Hotel Hansthol m in Hansthollllt Denmark. From areas of cell biology, bio...
It is perhaps obvious to any student of Biology that the discovery of chemical processes in whole organisms has usually preceded the elucidation of the compo nent steps. However, it is perhaps less...
1. Secondary Metabolism and Differentiation In addition to the primary metabolic reactions, which are similar in all living beings (formation and breakdown of nucleic acids and proteins as well as of...
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