The main goal of this edited book is to provide state-of-the art reviews of ion-atom and ion-molecule collisions at intermediate and high impact energies. Both experimental and theoretical methods are presented by experienced and active researchers in this field. The focus is upon the important processes with transitions of one or two electrons, such as electron capture, ionization, etc. The contents are suitable for graduate students as well as both junior and senior researchers. For the addressed topic, the literature has recently witnessed a veritable renaissance in experiment and theory. This subject is of high relevance in several branches of science and technology, e.g. accelerator-based physics, thermonuclear fusion research, plasma physics, astrophysics, particle transport physics, etc. Other important applications are in life sciences via medicine, where high-energy ion beams are used in hadron therapy for which a number of storage ring accelerators are either in full operation, under construction or planned to be built worldwide. Therefore, it is high time to present this field in its full capacity with the emphasis on the prospects for cross-disciplinary fertilization. This book is unique in more than one way. It transcends the field of ion-atom/molecule collisions from a joint perspective: experiment and theory expounded together in a complementary manner. It is wide in scope ranging from tackling the current controversies in experiments/theories to presenting benchmark deterministic computations as well as stochastic simulations and dealing with outreach to problem areas in cross-disciplinary research fields. It is the first book presenting the invited lectures at ISIAC (International Symposium on Ion-Atom Collisions), a biennial conference whose Jubilee 25th event occurred in 2017. It makes interesting reading to see chapter-by-chapter how the invited leading authors present the past and current status of experiment and theory. To aid the general reader, all the authors of 11 chapters tried to present their chapters in the context of the development of the addressed particular themes and the underlying major ideas and intricacies. Whenever possible, the authors made their attempts to connect the basic research in atomic/molecular collision physics with some important applications in other branches of physics as well as across the physics borders. The material presented in this should be interesting and useful to graduate students as well as to both junior and senior researchers. The contents and expositions should be helpful to the beginners in assessing the potential overlap of some of the presented material with their own research themes so as to gain additional motivations for possible further upgrades. Likewise, specialists could take advantage of these state-of-the-art reviews to see where the addressed themes were and where they are going in order to acknowledge the fruits of the labor made thus far as well as actively contribute to tailoring the directions of future research.