This book describes the design, physicochemical characterisation and clinical evaluation of bioadhesive drug delivery systems for photodynamic therapy of difficult-to-manage vulval neoplasias and dysplasias. In photodynamic therapy (PDT), a combination of visible light and a sensitising drug causes the destruction of selected cells. ALA is commonly delivered to the vulva using creams or solutions, which are covered with an occlusive dressing to aid retention and enhance drug absorption. Such dressings are poor at staying in place at the vulva, where shear forces are high in mobile patients. To overcome the problems associated with delivery of ALA to the vulva, we produced a bioadhesive patch by a novel laminating procedure. The ALA loading was 38 mg cm-2. Patches were shown to release more ALA over 6 hours than the proprietary cream. The ALA concentration in tissue at 2.375 mm was an order of magnitude greater than that found to be cytotoxic to HeLa cells. Clinically, the patch was used in successful PDT of vulval intraepithelial neoplasia, lichen sclerosus, squamous hyperplasia, Paget's disease and vulvodynia.
Photodynamic Therapy of Vulval Neoplasias and Dysplasias
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Description
This book describes the design, physicochemical characterisation and clinical evaluation of bioadhesive drug delivery systems for photodynamic therapy of difficult-to-manage vulval neoplasias and dysplasias. In photodynamic therapy (PDT), a combination of visible light and a sensitising drug causes the destruction of selected cells. ALA is commonly delivered to the vulva using creams or solutions, which are covered with an occlusive dressing to aid retention and enhance drug absorption. Such dressings are poor at staying in place at the vulva, where shear forces are high in mobile patients. To overcome the problems associated with delivery of ALA to the vulva, we produced a bioadhesive patch by a novel laminating procedure. The ALA loading was 38 mg cm-2. Patches were shown to release more ALA over 6 hours than the proprietary cream. The ALA concentration in tissue at 2.375 mm was an order of magnitude greater than that found to be cytotoxic to HeLa cells. Clinically, the patch was used in successful PDT of vulval intraepithelial neoplasia, lichen sclerosus, squamous hyperplasia, Paget's disease and vulvodynia.
Covering all aspects of photodynamic therapy, 70 expert contributors from the fields of photochemistry, photobiology, photophysics, pharmacology, oncology and surgery, provide multidisciplinary...
Photodynamic therapy is a proven effective treatment of actinically damaged skin cells, nonmelanoma skin cancers, and acne and other pilosebaceous conditions. As an agent for general facial...
The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the...
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